Abstract Library

#2945 Misdiagnosis of Pancreatic Neuroendocrine Carcinoma - A Potential Threat

Introduction: Pancreatic neuroendocrine tumors (PNETs) are a rare clinical entity.Very less data is available in Pakistan on PNETs.Common metastatic sites are liver, lung and brain Reports involving metastasis to breast are almost negligible.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author:

Authors: Athar A,

Keywords: Breast Carcinoma, PNETs, Misdiagnosis,

#2173 Decreased Serum Amyloid A1 as Potential Diagnostic Marker for Gastro-Entero-Pancreatic Neuroendocrine Neoplasms

Introduction: Gastro-entero-pancreatic neuroendocrine neoplasms (GEP-NENs) are rare tumors with an increased incidence reported in recent years. Researchers have shown that tumor cells produce and secrete more exosomes compared with normal cells. Serum amyloid A1 (SAA1) is elevated in patients with liver cancer, lung cancer, breast cancer, prostate cancer and endometrial cancer. However, the relation between SAA1 and GEP-NENs remains unclear.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author: Qiyun T

Authors: Na H, Qiyun T,

Keywords: Exosomes, Serum amyloid A1, Circulating biomarkers, Diagnosis,

#1592 Primary Neuroendocrine Carcinoma of the Breast: A Diagnostic Approach to the Special Type of Breast Malignancy

Introduction: WHO classification from 2003 defines primary neuroendocrine carcinomas (NEC) of the breast as a group of tumors with expression of neuroendocrine markers in more than 50% of tumor cells. In the current WHO classification this category is renamed to “carcinomas with neuroendocrine features” without defined clear-cut of the percentage of tumor cells positive for neuroendocrine markers.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author: Demirovic A

Authors: Demirović A, Vranic S, Skenderi F, Peric Balja M, Ulamec M,

Keywords: breast cancer, special types, carcinoma with neuroendocrine features, neuroendocrine markers,

#1560 Cannabinoids as Inhibitor of Tumour Growth and Invasiveness in Small Intestine Neuroendocrine Cancer

Introduction: Tumour cell invasion and proliferation is a key factor for the prognosis and progression of cancer. A recent study revealed that cannabinoids can inhibit tumour invasion and proliferation in breast cancer through the down-regulation of ID-1, an inhibitor of helix-turn-helix transcription factors.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author: Errampalli R

Authors: Errampalli R, Reicher A, Kleinegger F, Hirschnöck T, Pfragner R,

Keywords: si-net, id1, cannabinoid​,

#1507 The CDK4/6 Inhibitor Palbociclib Induces Anti-proliferative Mechanisms in Gastroenteropancreatic Neuroendocrine Neoplasms In Vitro

Introduction: Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are rare tumors with heterogeneous molecular backgrounds and mostly unknown druggable driver mutations. Especially for the midgut NENs effective treatment options are limited. The retinoblastoma pathway is often inactive due to CDK4/6 overexpression in pancreatic NENs. Palbociclib is a FDA approved (ER-positive and HER2-negative breast cancer) cyclin-dependent kinases 4 and 6 inhibitor and might impair cell cycle progression and proliferation.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author: Briest F

Authors: Briest F, Grass I, Siegmund B, Grabowski P,

Keywords: GEP-NEN, targeted therapy, cyclin-dependent kinases 4/6,